WebAbstract ：Two cDNA subtractive libraries of Monascus were constructed by suppression subtractive hybridization(SSH) andscreened of correlative genes from the citrinin biosynthetic pathway in Monascus species. All clones in the two libraries weresequenced and the results were analyzed by bioinformatic softwares. WebMar 1, 2016 · The pathway rules out alternatives involving intramolecular rearrangements, and fully defines the molecular steps for the first time and …
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Citrinin is a mycotoxin which is often found in food. It is a secondary metabolite produced by fungi that contaminates long-stored food and it causes different toxic effects, like nephrotoxic, hepatotoxic and cytotoxic effects. Citrinin is mainly found in stored grains, but sometimes also in fruits and other plant products. See more Citrinin was one of the many mycotoxins discovered by H. Raistrick and A.C. Hetherington in the 1930s. In 1941 H. Raistrick and G. Smith identified citrinin to have a broad antibacterial activity. After this discovery the … See more Citrinin is a polyketide mycotoxin, which is a secondary metabolite of some fungi species. Its IUPAC name is (3R,4S)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid and the molecular formula is C13H14O5. Citrinin has a … See more Citrinin is biosynthesized by fungi species of Penicillium, Monascus and Aspergillus. For the production of citrinin, a minimal set of genes is needed. These genes are conserved in most … See more Reddy et al. (1982) described the distribution and metabolism of [ C]Citrinin in pregnant rats. These rats were subcutaneously administered with 35 mg/kg C-labeled citrinin on day 12 of pregnancy. From plasma concentrations it could be concluded … See more The existing information on occurrence of citrinin in food suggests that relatively high citrinin concentrations can be found in stored grains and … See more There are different types of toxicity. The types of toxicity that have been studied for citrinin are acute toxicity, nephrotoxicity, genotoxicity and its carcinogenicity. Acute toxicity See more Various in vitro studies have revealed the involvement of citrinin toxicity in reduced cytokine production, inhibition of RNA and DNA synthesis, … See more WebFeb 21, 2024 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its regulation mechanism in P. citrinum is rarely reported. In this study, we investigated the effect of different carbon sources on citrinin production …
WebFeb 26, 2024 · When data mining was performed on citrinin targets, the top five functional descriptions were a cell’s response to an organic cyclic compound, the netrin–UNC5B … WebMar 30, 2024 · The disruption of MPs biosynthesis pathway can increase the production of citrinin, which may be due to more initial and extension units for citrinin biosynthesis. This illustrated that blocking of citrinin or pigment biosynthesis could significantly cause a change in their production in M. purpureus , and there is a mutual regulation between ...
WebMay 27, 2024 · In our bodies, toxins are detoxed and excreted through a few pathways. Routes of elimination include urine, stool, bile and through our skin. Other routes include tears and saliva but are negligible in the realm of detoxification. ... This prebiotic has been shown to bind to citrinin, which a wide variety of molds produce. Using a variety of ... WebJan 1, 1999 · Biosynthesis of citrinin and synthesis of its biogenetic precursors L. Colombo, C. Gennari, D. Potenza, C. Scolastico, F. Aragozzini, C. Merendi Chemistry 1980 …
WebSep 29, 2011 · In this paper, we describe the cloning and characterization of a 43 kb genomic DNA region of M. aurantiacus, which codes for 16 of the assumed genes of the …
WebOct 1, 2024 · The citrinin pathway belongs to the former as it is present in many Penicillium, Aspergillus, and Monascus species [30, 44, 45]. However, the biosynthetic gene cluster of Monascus azaphilone pigments is limited in the Monascus genera. The biosynthetic process of secondary metabolites forms a cluster or non-clustered gene … t shirt printing training in new orleansWebCitrinin C13H14O5 CID 54680783 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. … philosophy\u0027s 07WebCitrinin appears to be toxic by multiple pathways including inhibition of nucleic acid synthesis, inhibition of microtubule assembly and tubulin polymerization, alteration of … t shirt printing toolsWebJun 1, 2007 · The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN is known to cause cell injury, including apoptosis, but the precise regulatory mechanisms of CTN action, particularly in stem cells and embryos, are … tshirt printing trinidadWebNational Center for Biotechnology Information t shirt printing trinidad port of spainWebDec 16, 2024 · He, Y. Construction of a High-Efficiency Gene Knockout System of Monascus ruber M7 and Analysis of the Biosynthetic Pathway of Citrinin. Ph.D. Thesis, Huazhong Agricultural University, Wuhan, China, 2015; pp. 113–118. [Google Scholar] He, Y.; Cox, R.J. The molecular steps of citrinin biosynthesis in fungi. t-shirt printing transfer paperWebSep 29, 2011 · In the citrinin biosynthesis pathway, the transcriptional activator (ctnA) is one of the important components in the citrinin cluster [53]. According to our qRT-PCR analysis (Figure 3B), the ... t shirt printing transfer machine