Cystine slc7a11
WebApr 12, 2024 · SLC7A11 and solute carrier family 3 member 2 (SLC3A2) constitute system Xc- together on the cell membrane, which exports glutamate and imports cystine at a 1:1 ratio. Cystine is rapidly transformed into cysteine intracellularly, the rate-limiting amino acid for the synthesis of GSH. WebAnti-xCT/SLC7A11 (extracellular) Antibody (#ANT-111) is a highly selective antibody directed against an epitope of the mouse cystine/glutamate transporter. The antibody can be used in western blot, immunohistochemistry, and live cell flow cytometry. The antibody recognizes an extracellular epitope and can potentially be used for detecting the protein …
Cystine slc7a11
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WebAug 25, 2024 · The glutamate/cystine antiporter SLC7A11/xCT enhances cancer cell dependency on glucose by exporting glutamate. Cancer cells with specific genetic … WebFeb 20, 2015 · VA Directive 6518 4 f. The VA shall identify and designate as “common” all information that is used across multiple Administrations and staff offices to serve VA …
Web与slc7a11在其他压力条件下已确立的促生存作用相反，在此我们报告了一个出乎意料的发现，即slc7a11过表达增强了癌细胞对葡萄糖的依赖性，并使癌细胞对葡萄糖饥饿诱导的细胞死亡更加敏感，相反，slc7a11缺乏则通过敲低或药理学抑制作用促进葡萄糖饥饿时癌 ... WebCystine transporter solute carrier family 7 member 11 (SLC7A11) encodes the light chain subunit xCT of system x c − and promotes GSH synthesis by mediating Cys uptake and Glu release [51, 71]. SLC7A11 is overexpressed in multiple human cancers and promotes tumor survival [ 72 – 74 ].
WebApr 3, 2024 · Most cellular cysteine is acquired through the system x C – antiporter, which exchanges extracellular, oxidized cysteine (cystine) for intracellular glutamate. Yet, germline deletion of the system x C – gene, Slc7a11, is well tolerated in unstressed mice , which suggests that normal cells have low basal cystine import requirements. We ... WebThe Cystine Analog (CA) in this kit can be taken up into cells via xCT, and the incorporated CA can be specifically detected using the Fluorescent Probe and Reducing Agent. ... L. Cao, K. Han, H. Zhang, J. Cui, X. Ma, S. Zhao, C. Zhao, S. Yin, L. Fan, H. Hu, "Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal ...
Web★ SLC7A11&SLC3A2 蛋白具有天然 ... Parker J L, Deme J C, Kolokouris D, et al. Molecular basis for redox control by the human cystine/glutamate antiporter system xc−[J]. Nature communications, 2024, 12(1): 7147. 2. Girardi E, César-Razquin A, Lindinger S, et al. A widespread role for SLC transmembrane transporters in resistance to ...
WebDec 8, 2024 · SLC7A11 also has a noticeably less charged tunnel leading to the extracellular gate compared to LAT1 and LAT2, which may also facilitate binding of the … oracle certified java programmer goldWebJan 27, 2024 · System Xc − (a cystine/glutamate antiporter system), belonging to the heterodimeric amino acid transporter (HAT) family, is composed of two subunits, a light-chain subunit SLC7A11 (xCT) and a heavy-chain subunit SLC3A2 (CD98, 4F2hc) [ 6 ]. The two subunits are connected by an extracellular covalent disulfide bond and play different … oracle certified java programmer gold se 8WebSLC7A11 (also known as XCT) is a member of a hetromeric, sodium-independent, anionic amino acid transport system. It is highly specific for cysteine and glutamate. SLC7A11 is … portsmouth uni apps anywhereWebApr 26, 2024 · SLC7A11 encodes the antiporter xCT that imports cystine, the oxidized dimer and main source of intracellular cysteine, and exports glutamate. Targeting xCT … portsmouth uni assessing your skills gapsWebSLC7A11 is a cystine/glutamate antiporter transmembrane protein that plays a critical role in mediating cystine uptake in negative modulation of ferroptosis and maintaining cell survival under oxidative stress conditions inhibits and is found to be overexpressed in multiple human cancers. 15,16 Consistent with this, it was shown that SLC7A11 ... oracle certified junior associateWebMar 30, 2024 · Most cancer cells obtain cystine via the SLC7A11 transporter. Once inside cells, cystine is converted to a related amino acid called cysteine, which is then used to build up glutathione, the most ... portsmouth uni accommodationWeb★ SLC7A11&SLC3A2 蛋白具有天然 ... Parker J L, Deme J C, Kolokouris D, et al. Molecular basis for redox control by the human cystine/glutamate antiporter system xc−[J]. Nature … portsmouth uni mres history