WebJun 21, 2016 · Background: We evaluated lipoprotein-associated phospholipase A2 (Lp-PLA2) activity in patients with stable coronary heart disease before and during treatment with darapladib, a selective Lp-PLA2 inhibitor, in relation to outcomes and the effects of darapladib in the STABILITY trial. Methods and results: Plasma Lp-PLA2 activity was … WebSep 28, 2011 · Lp-PLA 2 was discovered on 1980 and it was classified as a Ca 2+ -independent PLA 2 [ 8 ], produced by a wide range of inflammatory and non-inflammatory cells [ 15 – 17 ]. It is considered a member of phospholipases family (PLA 2 ), although exhibits different properties when compared to other PLA 2 [ 18 ].
Therapeutic Options to Reduce Lp-PLA2 Levels and the …
WebThe principal aim of this study was to examine whether darapladib (a selective Lp-PLA2 inhibitor) could reduce the elevated Lp-PLA2 and Rho kinase activity in atherosclerosis. Materials and methods: The atherosclerosis rats were prepared by feeding them with a high-cholesterol diet for 10 weeks. WebJan 12, 2024 · The Lp-PLA2 phospholipase enzyme is an inflammatory marker associated with atherosclerosis, and is mainly produced by inflammatory cells. 20,28 –30 Lp-PLA2 concentration had been shown to alter considerably during the early phase of acute coronary syndrome; 31 plasma Lp-PLA2 concentration decreased gradually in patients with acute … nouryon paints and coatings
Lp-PLA Activity - Know Your Risk
WebJan 28, 2024 · Causes of High Lp-PLA2. Causes listed below are commonly associated with high Lp-PLA2 levels. Work with your doctor or another health care professional to get an … WebNov 23, 2024 · Lp-PLA2 has high specificity for vascular inflammation and been proposed to be a risk marker of CVD based on many epidemiological studies and meta-analyses 13, 14. However, most of these... WebAug 9, 2024 · Abstract High-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) have been reported to be independent predictors of atherosclerosis. However, whether the ... how to sign up for job corps