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Phospho-eif2α ser51 d9g8

Webgsk2606414是一种选择性的perk抑制剂，ic50值为0.4 nm[1]。 prkr样内质网激酶或蛋白激酶r（pkr）样内质网激酶（perk），也被称为真核翻译起始因子2-α激酶3（eif2ak3），属于i型膜蛋白家族。perk位于内质网（er）中，被错误折叠蛋白引起的er应激所诱导。perk通过磷酸化真核翻译起始因子2（eif2）的α亚基，从而 ... Web5199 Phospho-eIF2α (Ser51) (D9G8) XPÒ Rabbit mAb (Biotinylated) 2.2. Kennzeichnungselemente Ergänzende Gefahrenmerkmale EUH210 - Sicherheitsdatenblatt auf Anfrage erhältlich 2.3. Sonstige Gefahren Kann allergische Reaktionen hervorrufen. Den vollen Wortlaut der H-Sätze und EUH-Sätze in diesem Abschnitt finden Sie in Abschnitt 16

NUPR1 interacts with eIF2α and is required for resolution of the ER …

WebThe inhibition of Hsp90 prolonged ERS through the degradation of IRE1α and the dephosphorylation of eIF2α. • The suppression of autophagy reduced the expression of GRP78 and phospho-eIF2α to aggravate ERS. • Hsp90-mediated UPR and mTOR-dependent autophagy jointly promoted ERS-induced apoptosis in As 3+ /Se 4+ combination-treated … WebMonoclonal Antibody for studying EIF2S1/eIF2-alpha (Ser52) phosphate. Cited in 5 publications. Validated for Western Blotting. Highly specific and rigorously validated in … ponds dark spot corrector cvs https://xavierfarre.com

Ribosome slowdown triggers codon-mediated mRNA decay …

WebColorectal cancer (CRC) is the most common intestinal malignancy, and nearly 70% of patients with this cancer develop metastatic disease. In the present study, we synthesized … WebStructural information on eIF2α reveals that Ser51 is located within a flexible loop, referred to as the Ser51 loop. Recently, we have shown that conformational change of the Ser51 … WebAntibody Duet for studying EIF2S1/eIF2-alpha/EIF2S1/eIF2-alpha (Ser52) phosphate in the research area. shanty acres homestead

Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Cell Signaling …

Category:Phosphorylation of eukaryotic initiation factor-2α (eIF2α …

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Phospho-eif2α ser51 d9g8

PhosphoPlus® eIF2α (Ser51) Antibody Duet Cell Signaling …

WebJun 8, 2024 · The phosphorylation of eIF2α occurs on serine 51 in response to the activation of one out of four eIF2α kinases 4, 5, 6. EIF2AK1, commonly known as heme-regulated … WebSpecificity / Sensitivity Phospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51.

Phospho-eif2α ser51 d9g8

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WebSep 28, 2024 · Primary antibodies against LC3A/B (4108S), PERK (C33E10) (3192S), phospho-PERK (Thr980; 16F8) (3179S), eIF2α (D7D3) XP ® (5324T), and phospho-eIF2α … Web(3398) Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb - Cell Signaling Technology - CiteAb 726 citations – A rabbit monoclonal antibody, raised against Eukaryotic translation …

WebThe phosphorylation of eIF2α at Ser51 is well known to prevent a step in the initiation of translation and thereby block global protein synthesis [45,46]. eIF2α was phosphorylated in response to various cellular stresses [53,54]. We found that isopanduratin A up-regulated the level of phospho-eIF2α (Ser 51) within 1 h. WebAnti-phospho-eIF2 α (pSer51) antibody produced in rabbit affinity isolated antibody Synonym (s): Anti-EIF-2, Anti-EIF-2A, Anti-EIF-2alpha, Anti-EIF2, Anti-EIF2A NACRES: NA.41 Pricing …

WebJan 6, 2024 · Activation of PERK leads to phosphorylation of the eukaryotic initiation factor 2α (eIF2α), which is a critical regulator of protein translation. Phosphorylated eIF2α prompts a dramatic reduction in protein translation to limit cellular amino acid consumption.

WebStructural information on eIF2α reveals that Ser51 is located within a flexible loop, referred to as the Ser51 loop. Recently, we have shown that conformational change of the Ser51 loop increases the accessibility of Ser51 to the kinase active site for phosphorylation.

WebSep 3, 2024 · Product-Name : Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb Size : 40 ul Price- (USD) : 135 USD Species-x-Reactivity : H, M, R, Mk, Dm Applications : Immunohistochemistry (Paraffin) Product-Category : Translational Control Shipping-Temp : AMBIENT Storage-Temp : -20°C Product-Type : Monoclonal Antibody MW : 38 Host : … shanty agencyWebAug 4, 2024 · Cell Signaling Technology's Phospho-eIF2alpha (Ser51) (D9G8) XP ® Rabbit mAb is a Rabbit monoclonal antibody. The Phospho-eIF2alpha (Ser51) (D9G8) XP ® … shanty adjectiveWebtarget protein. Phospho-eIF2α (Ser51) (D9G8) XP® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Phospho-SAPK/JNK (Thr183/Tyr185) (81E11) Rabbit mAb detects endogenous levels of p46 and p54 SAPK/JNK only when phosphorylated at Thr183 and … shanty aleWebMay 3, 2024 · Stress-responsive kinases phosphorylate eIF2α at conserved Ser51, transforming eIF2 from substrate into a competitive GEF inhibitor. ... yet eIF2Bα deletion impairs phospho-inhibition of eIF2B, consistent with the subunit’s role in binding eIF2α-P. Point mutations with identical phenotypes cluster at the interface between eIF2Bα and ... ponds dreamflower powder benefitsWebSep 22, 2013 · During UPR, activated protein kinase-like ER kinase (PERK) phosphorylates eukaryotic translation initiation factor 2 subunit α (eIF2α) at Ser51 (Schröder and Kaufman 2005 ), resulting in inhibition of translation to prevent the synthesis of most proteins. ponds dreamflower powderWebOct 26, 2024 · Press release content from Business Wire. The AP news staff was not involved in its creation. ponds dreamflowerPhospho-eIF2α (Ser51) (D9G8) XP ® Rabbit mAb detects endogenous eIF2α only when phosphorylated at Ser51. The antibody does not recognize elF2α phosphorylated at other sites. Human eIF2alpha residue Ser52 historically has been referenced as Ser51. Species Reactivity: Human, Mouse, Rat, Monkey, D. melanogaster shanty 2 chic wall cabinet